Aflibercept for choroidal neovascularizations secondary to pseudoxanthoma elasticum: a prospective study

Intravitreal Bevacizumab Injection for Choroidal Neovascularisation Secondary to Angioid Streaks in Pseudoxanthoma Elasticum Patients

Submit Manuscript | http://medcraveonline.com Abbreviations: IVB: Intravitreal Bevacizumab; CNV: Choroidal Neovascularization; AS: Angioid Streaks; PXE: Pseudoxanthoma Elasticum; FFA: Fundus Fluorescein Angiography; OCT: Optical Coherence Tomography; RPE: Retinal Pigment Epithelium; PDT: Photo Dynamic Therapy; VEGF: Vascular Endothelial Growth Factor; AMD: Age-related Macular Degeneration; BCVA...

Pseudoxanthoma elasticum

Pseudoxanthoma elasticum (PXE) is a genetic metabolic disease with autosomal recessive inheritance caused by mutations in the ABCC6 gene. The lack of functional ABCC6 protein leads to ectopic mineralization that is most apparent in the elastic tissues of the skin, eyes and blood vessels. The clinical prevalence of PXE has been estimated at between 1 per 100,000 and 1 per 25,000, with slight fem...

Pseudoxanthoma elasticum

Successful long-term management of choroidal neovascularization secondary to angioid streaks in a patient with pseudoxanthoma elasticum: a case report

INTRODUCTION We describe the long-term effectiveness and tolerability of intravitreal vascular endothelial growth factor inhibitor ranibizumab in a patient with pseudoxanthoma elasticum with bilateral macular choroidal neovascularization secondary to angioid streaks. CASE PRESENTATION A 54-year-old Caucasian man with history of heart disease presented with visual loss in his right eye. An exa...

Periumbilical perforating pseudoxanthoma elasticum.

A 58-year-old, gravida 6, obese woman presented with a pruritic yellowish plaque around the umbilicus, which first appeared about 3 years ago. She also had flat yellow papules on the axilla and neck. After a burn from a heating device, a few perforating papules and a violaceous hue occurred on the plaque. Histological examination revealed pathological elastic fibers with a keratotic plug and pe...